Buffalo Bills travel to NRG Stadium, Houston, TX for the opening week of the 2026 season, kick-off Sunday 13 September at 17:00 UTC, live on CBS.
Buffalo Bills finished the 2025 season 12-5 and took the 6th seed in the AFC. Houston Texans finished 12-5 and took the 5th seed.
The opening line has it at BUF -1.5 with a total of 44.5, which tells you the market is treating this as a home-field game rather than a mismatch.
Longer term, the interesting question is repeatability. Turnover margin swings from season to season; yards per play does not, and that is the number to trust in a projection.
DeMeco Ryans is in charge on the home sideline, with Joe Brady opposite him. Week one form is famously unreliable, but the openers still set the tone for a division race that runs to January.
